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Leukemia

News, opinions and meeting coverage in oncology/hematology.

EHA over a photo of IFEMA Madrid in Spain.

Three-Drug Regimens Make Case for a Role in Untreated and Relapsed/Refractory CLL

Undetectable MRD rates of 90% or higher, PFS of 7 years or more

EHA over a photo of IFEMA Madrid in Spain.

New Standard of Care in High-Risk Acute Promyelocytic Leukemia?

All-trans retinoic acid plus arsenic trioxide and idarubicin improved EFS over standard

A computer rendering of CAR T cell therapy in Diffuse large B-cell lymphoma

New Clues to Origin of T-Cell Lymphoma After CAR-T Therapy

Co-mutations, viral link, potential common susceptibility emerge from two studies

FDA APPROVED imetelstat (Rytelo) over a photo of a bag of blood in blue rubber gloved hands.

Telomerase Inhibitor Approved for MDS-Related Anemia

Imetelstat indicated for lower-risk myelodysplastic syndromes with transfusion-dependent anemia

Onco Break over a computer rendering of a cancer cell.

'Unusual' Cancers After Pandemic; A Win in TNBC; Shortage Pauses Clinical Trial

News, features, and commentary about cancer-related issues

Morning Break over illustration of a syringe, Covid virus, and DNA helix over a photo of green vegetation.

Star Singer's Illness; AI Imitating the Dead; Internet-Addicted Brains

Health news and commentary gathered by 口袋女优 staff

ASCO over a photo of McCormick Place, in Chicago, IL

STAMP Inhibitor Tops Imatinib, Second-Gen TKIs for Newly Diagnosed CML

The benefit-risk profile could change the treatment paradigm in CML, expert says

Onco Break over a computer rendering of a cancer cell.

Ignoring Colonoscopy Advice; Inflamed Tongue, Then Cancer; Acupuncture for Dry Mouth

News, features, and commentary about cancer-related issues

A close up photo of a woman鈥檚 hand with an IV line attached.

Ending Oncology's Toxic Relationship With High Chemotherapy Doses

Optimizing doses can improve patient outcomes and lower costs

A computer rendering of acute myeloid leukemia cells in the blood.

Venetoclax Combo Safe, Effective in AML Patients Age 80 and Up, Real-World Data Show

Study finds survival is comparable to that seen in younger patients in VIALE-A trial

A photo of a couple holding hands during a meeting with a fertility doctor.

Fresh and Frozen Embryo Transfers May Increase Risk of Childhood Leukemia

However, overall cancer risk was not higher after fertility treatments vs natural conception

Illustration of blood cells with circulating tumor cells.

High Deep-Remission Rate With Triple Regimen for Relapsed/Refractory CLL

Undetectable disease rate over 90%, ctDNA also promising for earlier detection of recurrence

Illustration of an engineered T-cell attacking a leukemia cell.

CAR-T Plus Stem-Cell Transplant Promising for CD7+ Blood Cancers

"All-in-one" approach appears safe, effective, in patients with relapsed/refractory disease

A photo of a pregnant woman napping while receiving chemotherapy.

Immunotherapy During Pregnancy Just as Safe as Other Cancer Drugs

However, use should be avoided "if possible" due to risk of rare immune-related adverse events

A photo of Hezaran Dorna paper cranes laying on a table.

1,000 Paper Cranes Can Bring Our Patients One Step Closer to Healing

We must remind our patients to hold on to hope

Onco Break over a computer rendering of a cancer cell.

Chemo and Heart Disease; Flawed Lung Cancer Screening; New Vax Recommendations

News, features, and commentary about cancer-related issues

A photo of a woman breastfeeding her baby at home.

Breastfeeding Tied to Reduced Childhood Leukemia Risk

Lower pediatric ALL risk in Danish study when mothers exclusively breastfed for 3 months or more

FDA APPROVED ponatinib (Iclusig) over a computer rendering of the destruction of lymphoblast cells

FDA Approves New Frontline Regimen for Aggressive ALL

Ponatinib lands indication in combination with chemo for Philadelphia chromosome-positive cases

Onco Break over a computer rendering of a cancer cell.

Broader Cancer Risk With CAR-T? AI for Physician Burnout; 'Lollipops' ID Oral Cancer

News, features, and commentary about cancer-related issues

A photo of a woman holding a tray of stainless equipment at a medical sterilization facility

EPA Imposes New Limit on Medical Sterilization Chemical, Citing Cancer Risk

Rule would lower emission standards for ethylene oxide by 90%, agency says

FDA APPROVED lisocabtagene maraleucel (Breyanzi) over a computer rendering of CLL cells in the blood stream.

FDA Approves First CAR-T for Chronic Lymphocytic Leukemia

Lisocabtagene maraleucel (Breyanzi) nabs new indication for relapsed or refractory CLL/SLL

FDA ODAC imetelstat (Rytelo) over a close up photo of a person receiving a blood transfusion.

FDA Panel Endorses Imetelstat for MDS-Related Anemia

By 12-2 vote, members find improvement in transfusion independence outweighs risk

Onco Break over a computer rendering of a cancer cell.

Getting Prostate Cancer Drugs Sooner; Limiting Toxic Emissions; FTC Sues 'Charity'

News, features, and commentary about cancer-related issues

FDA ODAC imetelstat (Rytelo) over a close up photo of a person receiving a blood transfusion.

FDA Staff Cast Doubt on Novel Drug for MDS-Related Anemia

Agency asking its advisors if benefits outweigh risks for patients who fail on standard treatment

Onco Break over a computer rendering of a cancer cell.

A Blenrep Comeback? Cancer Vaccine for Dogs; U.K. Snubs Enhertu

News, features, and commentary about cancer-related issues

A computer rendering of acute myeloid leukemia cells in the blood

All-Oral AML Regimen Shows Promise for Older, Unfit Patients

Response rate of 64% in newly diagnosed patients, 46% in those with refractory/relapsed disease

A photo of families holding handwritten signs at a protest outside a sterilization plant in Illinois.

Toxic Gas That Sterilizes Medical Devices Prompts Safety Rule Update

The EPA is set to take action after public outcry

Onco Break over a computer rendering of a cancer cell.

New Drugs Yield Limited Benefit; Big Jump in Drug Prices; AI Boost for Mammo Results

News, features, and commentary about cancer-related issues

A scanning electron microscope image of an HIV-1 virus.

Oldest Patient 'Cured' of HIV Still in Remission 5 Years After Transplant for AML

But it's unlikely stem cell transplants will ever be large-scale cure for HIV, says expert

A computer rendering of acute myeloid leukemia cells

FLT3 Inhibitor Highly Active in Newly Diagnosed Acute Myeloid Leukemia

Complete response rate of 86%, median event-free survival approaching 4 years with crenolanib

Onco Break over a computer rendering of a cancer cell.

No Relief From Drug Shortages; New Lymphedema Guideline; A 'Good' Patient No More

News, features, and commentary about cancer-related issues

A computer rendering of a cancer cell amongst red blood cells.

All-Oral Therapy Promising in Higher-Risk MDS, CMML

In small trial, overall response rate was 95%

A photo of Marines participating in formation exercises at Camp Lejeune.

Camp Lejeune Water Contamination Tied to a Range of Cancers, CDC Study Says

Health risks now more firmly established, but study falls short of being definitive

A computer rendering of T-cells attacking growing cancer cells.

When a Revolutionary Cancer Treatment Causes Cancer

The potential benefits of CAR T-cell therapies still far outweigh the risks

A computer rendering of CAR-T immunotherapy.

CAR-T Investigation: FDA Leaders Detail Decision on Cancer Risk Warning

Post-treatment cases grow to 22 since products' initial approvals

A computer rendering of CAR T cells and a cancer cell.

FDA Calls for New Boxed Warning on All CAR-T Products

Most serious warning would alert patients, providers on potential risk for secondary malignancies

Onco Break over a computer rendering of a cancer cell.

Two Million Cancers; Casgevy OK'd for Thalassemia; Rectal Exams and Prostate Cancer

News, features, and commentary about cancer-related issues

A photo of the packaging and blisterpack of Carvedilol tablets

Carvedilol No Help in Preventing Heart Failure in Childhood Cancer Survivors

While safe, the results do not support use of the drug in anthracycline-exposed survivors

ASH over a photo of San Diego Convention Center.

Menin Inhibitor Yields 63% ORR in Heavily Pretreated Acute Leukemia

Investigational drug revumenib now under review at FDA for KMT2A-rearranged disease

ASH over a photo of San Diego Convention Center.

MRD Tied to Allo-Transplant Benefit in NPM1-Mutated Acute Myeloid Leukemia

No advantage for MRD-negative patients in first remission after induction, regardless of FLT3 ITD

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